S119-8

SKU: orb1309136

Description

RN-18 is a small molecule that specifically counteracts HIV-1 Vif function, leading to increased levels and virion incorporation of the antiviral protein APOBEC3G (A3G). This action enhances cytidine deamination of the viral genome and reduces viral infectivity, providing a valuable tool for studying HIV-1 host restriction mechanisms in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 443639-96-1
• MW: 344.45
• Purity: 99.83% (May vary between batches)
• Formula: C₂₃H₂₄N₂O
• SMILES: CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(Nc2ccccc2)cc1
• Target: Influenza Virus
• Solubility: DMSO:55 mg/mL (159.67 mM)

Bioactivity

• In Vitro:
  RN-18, that antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, influenza, Influenza B, Influenza Virus, InfluenzaVirus, inhibit, spectrum, S119 8, S1198, S-119-8, S119-8, viruses

Compound Identifiers

PubChem CID

1787280