S07-2010

SKU: orb1688550

Description

S07-2010 is a potent inhibitor of AKR1C enzymes (AKR1C1-C4) with demonstrated anti-cancer activity. It induces apoptosis and exhibits significant cytotoxicity in drug-resistant cell lines such as A549/DDP and MCF-7/DOX, making it a valuable tool for studying chemoresistance and oncology research in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1223194-71-5
• MW: 371.45
• Purity: 98.13% (May vary between batches)
• Formula: C₁₉H₂₁N₃O₃S
• SMILES: O=C1N=C(SCC(=O)C2=CC=C3NC(=O)CCCC3=C2)NC(=C1)CCC
• Target: Others,NADPH,Reductase
• Solubility: DMSO:30 mg/mL (80.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM)

Bioactivity

• Target IC50:
  AKR1C3:0.19 μM|AKR1C1:0.47 μM|AKR1C2:0.73 μM|AKR1C4:0.36 μM
• In Vitro:
  S07-2010 (0-25 μM, 48h) was shown to be cytotoxic to MCF-7/DOX and A549/DDP with IC50 = 127.5 and 5.51 μM. In A549/DDP cells, S07-2010 can significantly reverse cancer cell resistance to DDP and inhibit tumor proliferation at low concentrations. In A549/DDP cells, the CI values of S07-2010 ranged from 0.2 to 0.6, indicating a strong synergistic drug effect in the combination therapy. S07-2010 (25 μM) can induce apoptosis of tumor cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S072010

Compound Identifiers

PubChem CID

135858320