S- (+)-Rolipram

SKU: orb1223027

Description

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.(In Vitro):(+)-Rolipram (0.015-1000 μM; 20 h) dose-dependently suppress LPS-induced TNF production of human mononuclear cells (MNC), with an IC50 of 550 nM.(In Vivo):(+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats.(+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats.

Key Properties

• CAS Number: 85416-73-5
• MW: 275.34
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₁NO₃
• SMILES: COC1=C(OC2CCCC2)C=C(C=C1)[C@H]1CNC(=O)C1
• Target: PDE4
• Solubility: DMSO : 100 mg/mL. 363.19 mM

Bioactivity

• In Vivo:
  (+)-Rolipram (0.025-6.25 mg/kg; a single i.p.) dose-dependently inhibits locomotor activity and induces head twitches in rats. (+)-Rolipram (0.06-25 mg/kg; a single i.p.) causes a dose-related fall in rectal temperature of rats.
• In Vitro:
  (+)-Rolipram (0.015-1000 μM; 20 h) dose-dependently suppress LPS-induced TNF production of human mononuclear cells (MNC), with an IC50 of 550 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(+)-Rolipram | (S)-Rolipram

Quick Database Links

Gene Symbol

PDE4