S-Isocorydine(+)

SKU: orb1222222

Description

Isocorydine is an alkaloid from root tubers of Stephania Kwangsiensis H.S. Lo.(In Vitro):Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387.Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines.(In Vivo):Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth.

Key Properties

• CAS Number: 475-67-2
• MW: 341.41
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃NO₄
• SMILES: CN1CCc2cc(c(c3c2[C@@H]1Cc1c3c(c(cc1)OC)O)OC)OC
• Target: Others
• Solubility: In Vitro: DMSO : 20 mg/mL (58.58 mM)

Bioactivity

• In Vivo:
  Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth. Animal model: Female nude mice. Dosage: 0.4 mg/ml. Administration: Injected intraperitoneally every 2 days for 2 weeks. Result: Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.
• In Vitro:
  Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387. Isocorydine (0-400 ug/ml; 48 hours)abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines. Cell Viability Assay Cell line: Huh-7, Hep-G2, SNU-387, SNU-449 cells. Concentration: 0-400 ug/ml. Incubation time: 24 hours. Result: Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone. Western blot analysis. Cell line: Huh-7, Hep-G2, SNU-387, SNU-449 cells. Concentration: Incubation time: 24 hours. Result: Downregulated protein levels of Claundin-1 and E-cadherin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isocorydine | Luteanin | d-Isocorydine | NSC32979

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Gene Symbol

Others