(S)-Indoximod

SKU: orb1303363

Description

(S)-Indoximod (L-Abrine) is a competitive IDO inhibitor that reduces Foxp3 expression and exhibits antitumor activity in mouse LLC allograft models. In vitro, it demonstrates antiproliferative effects against LLC cells. This small molecule is a research tool for studying immunomodulation and cancer therapy in both cellular and animal systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 21339-55-9
• MW: 218.25
• Purity: 99.69% (May vary between batches)
• Formula: C₁₂H₁₄N₂O₂
• SMILES: Cn1cc(C[C@H](N)C(O)=O)c2ccccc12
• Target: Indoleamine 2,3-Dioxygenase (IDO),IDO
• Solubility: DMSO:Slightly soluble;0.1 M NaOH:10 mg/mL (45.82 mM)

Bioactivity

• Target IC50:
  IDO:3-Dioxygenase

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2,3-dioxygenase, 1-Methyl-L-tryptophan, (S)Indoximod, (S)-Indoximod, (S) Indoximod, Abrine, L-Abrine, IDO, Indoximod, Indoleamine2,3Dioxygenase(IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, indoleamine, Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase, N-ME-Tryptophan

Compound Identifiers

PubChem CID

676159