S-BAY-8040

SKU: orb746537

Description

S isomer of BAY-8040.Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

Key Properties

• MW: 427.38
• Purity: > 98%,Standard References
• Formula: C₂₁H₁₆F₃N₅O₂
• SMILES: C(C1C=CC([C@H]2NC(=O)N(C3C=C(C(F)(F)F)C=CC=3)C3=C2C(NN(C3)C)=O)=CC=1)#N

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

44480524