S-Adenosyl-L-methionine disulfate tosylate

SKU: orb1300498

Description

S-Adenosyl-L-methionine disulfate tosylate is an orally active methyl donor supplement. It is studied for its roles in depression, pain management, and liver and osteoarthritis research. In vitro and in vivo studies also indicate potential anti-cancer properties, including anti-proliferative and pro-apoptotic effects.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 97540-22-2
• MW: 766.8
• Purity: 99.98% (May vary between batches)
• Formula: C₂₂H₃₄N₆O₁₆S₄
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
• Target: Endogenous Metabolite,DNA/RNA Synthesis,Apoptosis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:72 mg/mL (93.9 mM);DMSO:247.5 mg/mL (322.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.52 mM)

Bioactivity

• In Vivo:
  METHODS: To investigate the effect of S-Adenosyl-L-methionine disulfate tosylate on ASD, S-Adenosyl-L-methionine disulfate tosylate (30 mg/kg) was administered orally to young rats for 3 days. RESULTS: S-Adenosyl-L-methionine disulfate tosylate could prevent ASD-like behaviors induced by valproic acid exposure early after birth in young rats. METHODS: To study the antiepileptic effect of S-Adenosyl-L-methionine disulfate tosylate, S-Adenosyl-L-methionine disulfate tosylate (50 mg/kg, 100 mg/kg) was orally administered to pentylenetetrazole-induced epilepsy rats. RESULTS: S-Adenosyl-L-methionine disulfate tosylate exhibited antiepileptic, memory enhancement and antioxidant properties in pentylenetetrazole-induced epilepsy rats.
• In Vitro:
  METHODS: Cal-33 and JHU-SCC-011 cells were treated with S-Adenosyl-L-methionine disulfate tosylate (300 µM) for 24 or 48 hours. Apoptosis and cell cycle were detected by flow cytometry. Cell migration was detected using the Scratch-wound assay. RESULTS: S-Adenosyl-L-methionine disulfate tosylate induces apoptosis and promotes cell cycle arrest in Cal-33 and JHU-SCC-011 cells, reducing the migration of Cal-33 and JHU-SCC-011 cells. METHODS: Human A549 lung cancer cells were treated with S-Adenosyl-L-methionine disulfate tosylate (5-40 μg/mL) for 48 hours, and the DNMTs protein level was detected by Western Blot method. RESULTS: S-Adenosyl-L-methionine disulfate tosylate protects the anti-cancer effect of 5-FU by regulating the expression of DNMTs.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, DNASynthesis, DNA Synthesis, APE1(Ref-1), AdoMet disulfate, Ademetionine disulfate, Ademetionine disulfate Tosylate, Ademetionine disulfate tosylate, SAdenosylLmethionine disulfate tosylate, S-Adenosyl-L-methionine disulfate Tosylate, S-Adenosyl methionine disulfate, S Adenosyl L methionine disulfate tosylate, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

45072193