(S)-3,4-DCPG HCl

SKU: orb1745248

Description

(S)-3,4-Dicarboxyphenylglycine hydrochloride is a potent and selective agonist for the metabotropic glutamate receptor 8 (mGluR8), exhibiting an EC50 of 31 nM in human mGluR8-expressing cell lines. This compound is a valuable research tool for investigating mGluR8 function in neuropharmacology, utilized in both in vitro assays and in vivo studies exploring synaptic transmission and neurological disorders.

Research Area

Neuroscience

Key Properties

• MW: 275.64
• Purity: 99.06% (May vary between batches)
• Formula: C₁₀H₁₀ClNO₆
• SMILES: OC(C1=C(C=CC([C@H](N)C(O)=O)=C1)C(O)=O)=O.[H]Cl
• Target: GluR
• Solubility: DMSO:10 mg/mL (36.28 mM)

Bioactivity

• Target IC50:
  mGluR8a (human):31 nM (EC50)
• In Vivo:
  (S)-3,4-DCPG (3-100 mg/kg, i.p.) maked c-Fos as an indicator of neuronal activity in specific brain regions 2 hours after systemic administration. In wild-type mice, (S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mGluR, 3,4-DCPG HCl, 3,4-DCPG HCl(201730-11-2 Free base), 3,4-Dicarboxyphenylglycine HCl, (S)-3,4-DCPG HCl(201730-11-2 Free base), (S)-3,4-Dicarboxyphenylglycine HCl

Compound Identifiers

PubChem CID

169553382