S 3304

SKU: orb1307710

Description

S 3304 is a selective small molecule inhibitor targeting matrix metalloproteinase-2 (MMP-2) and MMP-9. It is widely used in vitro and in vivo to study tumor metastasis, angiogenesis, and inflammatory diseases involving these gelatinases.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 203640-27-1
• MW: 464.56
• Purity: 98.09% (May vary between batches)
• Formula: C₂₄H₂₀N₂O₄S₂
• SMILES: Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
• Target: MMP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);DMSO:83.3 mg/mL (179.31 mM)

Bioactivity

• In Vivo:
  S 3304 (p.o., the dose range of 20 to 200 mg/kg) treatment, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 cause effective inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen .
• In Vitro:
  S 3304 is a novel D-tryptophan derivative and a potent, noncytotoxic matrix metalloproteinase inhibitor. It most effectively inhibits MMP-2 and MMP-9 activities but does not inhibit MMP-1, MMP-3, or MMP-7, potentially avoiding the musculoskeletal side effects associated with nonspecific inhibitors .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S3304, S-3304, S 3304, Matrix metalloproteinases, Inhibitor, inhibit, MMP-2, MMP-9, MMP

Compound Identifiers

PubChem CID

10718956