(S)-3-Hydroxyphenylglycine

SKU: orb1305675

Description

(S)-3-Hydroxyphenylglycine is a selective agonist for group I metabotropic glutamate receptors (mGlu1 and mGlu5). It is a valuable research tool used in both in vitro and in vivo studies to investigate synaptic plasticity, neuronal excitability, and the roles of mGluRs in neurological disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 71301-82-1
• MW: 167.16
• Purity: 99.65% (May vary between batches)
• Formula: C₈H₉NO₃
• SMILES: N[C@H](C(O)=O)c1cccc(O)c1
• Target: GluR
• Solubility: H2O:6.56 mg/mL (39.24 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Hippocampal neurons in the slice preparation exhibit spontaneous synchronized bursting activity in the presence of picrotoxin, a γ-aminobutyric acid-A receptor antagonist. These synchronized bursts rarely exceed 500 ms in duration and thus resemble interictal discharges. Control shows one such synchronized burst, which typically consisted of an initial abrupt discharge 100–200 ms in duration (primary burst) followed by a series of briefer phasic discharges (secondary bursts). Addition of (S)-3-hydroxyphenylglycine (250–500 μM) significantly prolonged the synchronized burst duration, primarily via a marked increase in the number of secondary bursts. These prolonged discharges ranged from 1 to 7 s in duration (4,282 ± 1,060 ms, a 1,021 ± 247% increase, n = 7), and the secondary bursts within each discharge gradually changed in amplitude and frequency.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mGluR1, 3-Hydroxyphenylglycine, (S) 3 Hydroxyphenylglycine, (S)3Hydroxyphenylglycine

Compound Identifiers

PubChem CID

6604712