Ruxolitinib S enantiomer

SKU: orb1223574

Description

The chirality of Ruxolitinib (INCB-018424), which is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.

Key Properties

• CAS Number: 941685-37-6
• MW: 306.365
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₈N₆
• SMILES: N#CC[C@@H](C1CCCC1)N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2
• Target: JAK
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: Female wild-type C57BL/6J or Nes-gfp27 mice with myeloproliferative neoplasms (MPNs) in peripheral blood. Dosage: 30 mg/kg (in 0.5% hydroxypropyl methylcellulose after solubilisation in DMSO). Administration: Oral gavage; twice per day separated 10-12 h for 8 weeks. Result: Reduced haematopoietic cell expansion in MPN but it did not rescue bone marrow (BM) mesenchymal stem cells (MSCs).
• In Vitro:
  RT-PCR Cell line: Human small airway epithelial cells (SAECs). Concentration: 10 μM. Incubation time: 12 hours. Result: Suppressed IFNβ-induced expression of ISG, IFIT, and IFITM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S-Ruxolitinib | INCB-018424 S enantiomer

Quick Database Links

Gene Symbol

JAK