RUVBL1/2 ATPase-IN-1

SKU: orb1297828

Description

RUVBL1/2 ATPase-IN-1 is a potent dual inhibitor of the RUVBL1 and RUVBL2 ATPases, exhibiting IC50 values of 6.0 μM and 7.7 μM, respectively. This compound is a valuable chemical probe for investigating the role of these AAA+ ATPases in oncogenic pathways, supporting cancer research in both cellular and biochemical studies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 423128-55-6
• MW: 507.55
• Purity: 99.92% (May vary between batches)
• Formula: C₂₈H₂₈F₃N₅O
• SMILES: Cc1ccc(Cc2c(C)nc3c(cnn3c2C)C(=O)N2CCN(CC2)c2cccc(c2)C(F)(F)F)cc1
• Target: Others,Proton pump
• Solubility: DMSO:8 mg/mL (15.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.97 mM)

Bioactivity

• Target IC50:
  RUVBL2:7.7 μM|RUVBL1:6.0 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

selective, RUVBL1, RUVBL1/2, RUVBL1/2 ATPase IN 1, RUVBL1/2 ATPaseIN1, RUVBL1/2 ATPase-IN-1, RUVBL2, inhibit, Inhibitor, cancer, AAA ATPases

Compound Identifiers

PubChem CID

4103510