RUNX1/ETO tetramerization-IN-1

SKU: orb1688939

Description

RUNX1/ETO tetramerization-IN-1 is a potent small-molecule inhibitor that disrupts the NHR2-mediated tetramerization of the RUNX1/ETO oncoprotein (EC50 = 0.25 µM). It restores downregulated gene expression, inhibits RUNX1/ETO-dependent leukemia cell proliferation in vitro, and demonstrates significant anti-tumor efficacy in mouse models of AML.

Research Area

Cancer Biology

Key Properties

• CAS Number: 88755-39-9
• MW: 342.3
• Formula: C₁₈H₁₄O₇
• SMILES: C(CC(=O)C=1C=C2C(=CC1)OCO2)(C(O)=O)C=3C=C4C(=CC3)OCO4
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

294348