RUNX1/ETO-IN-1

SKU: orb3135283

Description

RUNX1/ETO-IN-1 is an inhibitor targeting the oncogenic fusion protein RUNX1-ETO, specifically affecting the NHR2 oligomerization domain. It binds directly to NHR2 (KD,app = 39 μM). By inducing apoptosis and promoting differentiation, RUNX1/ETO-IN-1 exhibits antileukemic activity in RUNX1/ETO translocation acute myeloid leukemia (AML) cells. Its near-neutral charge under physiological pH conditions grants it excellent cell membrane permeability.

Research Area

Cancer Biology, Cell Biology

Key Properties

• CAS Number: 923865-06-9
• MW: 399.51
• Formula: C₂₁H₂₅N₃O₃S
• SMILES: O=C1C=C(N=C2SC=C(N12)C)CNC(C3=CC=C4OCCCOC4=C3)C(C)C
• Target: Apoptosis,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Others