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Ruboxistaurin

SKU: orb1687029

Description

Ruboxistaurin (LY333531) is a potent and selective oral inhibitor of PKC beta isoforms, exhibiting competitive, ATP-dependent inhibition with IC50 values of 4.7 nM (PKC beta I) and 5.9 nM (PKC beta II). It has been widely used in preclinical research, including in vitro signaling studies and in vivo models of diabetic microvascular complications.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number169939-94-0
MW468.55
FormulaC28H28N4O3
SMILESCN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
TargetPKC,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information