Rubiadin-1-methyl ether

SKU: orb1303033

Description

Rubiadin-1-methyl ether is a natural compound that suppresses osteoclast-mediated bone resorption. It functions by inhibiting NF-κB pathway activation, specifically blocking p65 phosphorylation, IκBα degradation, and p65 nuclear translocation. This mechanism supports its research application in studying bone metabolism disorders such as osteoporosis in cellular models.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 7460-43-7
• MW: 268.26
• Purity: 98.32% (May vary between batches)
• Formula: C₁₆H₁₂O₄
• SMILES: COc1c(C)c(O)cc2C(=O)c3ccccc3C(=O)c12
• Target: Anti-infection,NF-κB
• Solubility: DMSO:2.69 mg/mL (10.03 mM)

Bioactivity

• In Vitro:
  To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rubiadin 1 methyl ether, Rubiadin 1-methyl ether, Rubiadin1methyl ether, Rubiadin-1-methyl ether, Nuclear factor-kappaB, Nuclear factor-κB, NFκB, NF-kB, NFkB, NF-κB, inhibit, Inhibitor, Antifection, Anti-infection, Antiinfection

Compound Identifiers

PubChem CID

96191