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RU320521

SKU: orb1220930

Description

RU.521 (RU320521) is a potent dsDNA inhibitor (IC50 : 700 nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

Images & Validation

Key Properties

CAS Number2262452-06-0
MW414.22
Purity>98% (HPLC)
FormulaC19H11Cl2N4O3
SMILESCc1nn(-c2nc3c(Cl)c(Cl)ccc3[nH]2)c(O)c1C1OC(=O)c2ccccc12
TargetDNA/RNA Synthesis
SolubilityDMSO:125 mg/mL (301.04 mM)

Bioactivity

In Vivo
Animal model: Male 8-week-old male mice with LPS injection. Dosage: 5 mg/kg. Administration: Intraperitoneal injection; 5 mg/kg once. Result: Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RU.521

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    2262452-06-0

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    C19H12Cl2N4O3

    2 mg, 10 mg, 50 mg, 100 mg, 5 mg, 25 mg, 1 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

RU320521 (orb1220930)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 250.00
25 mg
$ 390.00
50 mg
$ 540.00
100 mg
$ 780.00