Ru-Poma

SKU: orb3134376

Description

Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• Formula: C₈₉H₇₅Cl₂N₁₁O₁₁Ru.7H₂O
• Target: Ligands for E3 Ligase,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ligands for E3 Ligase,Ferroptosis