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RTx-161

SKU: orb3134172

Description

RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. It selectively kills HR-deficient cancer cells and inhibits PARP inhibitor (PARPi) resistance across various genetic backgrounds, including HR-proficient cells. RTx-161 also induces apoptosis.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

FormulaC21H18F7N3O4
TargetApoptosis,DNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information