RS-67333

SKU: orb1702850

Description

RS-67333 is a selective 5-HT4 receptor partial agonist with demonstrated neuroprotective properties. Research in the 5XFAD Alzheimer's disease mouse model shows it can reduce amyloid pathology and associated cognitive deficits, supporting its use in neurodegenerative disease research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 160845-95-4
• MW: 352.9
• Purity: 99.24% (May vary between batches)
• Formula: C₁₉H₂₉ClN₂O₂
• SMILES: O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2
• Target: 5-HT Receptor

Bioactivity

• Target IC50:
  5-HT4 receptor:8.7 (pKi)
• In Vitro:
  RS-67333 exhibits affinity for the 5-HT4 binding site in the guinea pig striatum (pKi = 8.7, respectively); and lower affinity (< 6.0) for several other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2, and muscarinic M1-M3 receptors. However, RS-67333 exhibits affinity for both the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RS67333, RS-67333, RS 67333

Compound Identifiers

PubChem CID

183782