RRD-251

SKU: orb3137099

Description

RRD-251 is a specific small-molecule disruptor of the Rb-Raf-1 interaction. By blocking the physical binding between the Rb protein and Raf-1 kinase, it inhibits downstream cell cycle progression and survival signaling without affecting Rb-E2F1 binding. Research indicates that RRD-251 effectively induces apoptosis in various tumor cells, particularly metastatic melanoma, and demonstrates significant synergistic enhancement in combination chemotherapy studies.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 72214-67-6
• MW: 271.59
• Purity: 99.95% (May vary between batches)
• Formula: C₈H₉Cl₃N₂S
• SMILES: Cl.ClC1=CC=C(C(Cl)=C1)CSC(=N)N
• Target: Raf,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Raf,Apoptosis