(R,R)-Birelentinib

SKU: orb3175156

Description

(R,R)-Birelentinib (Compound 14) is a potent BTK inhibitor with IC50 values of 0.7 nM for BTKWT and 0.86 nM for BTKC481S. It effectively inhibits BTK autophosphorylation with an IC50 of 24.3 nM. This compound exhibits significant antiproliferative activity against both wild-type and C481S mutant HEK293 cells, and is useful for studying resistant B-cell malignancies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2662512-14-1
• MW: 453.45
• Formula: C₂₃H₂₁F₂N₅O₃
• SMILES: NC=1C2=C(N=C(N2N=CN1)[C@H]3CC[C@H](CO)OC3)C4=CC=C(OC5=C(F)C(F)=CC=C5)C=C4
• Target: BTK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BTK