RR-11a analog

SKU: orb1708641

Description

RR-11a analog (7a) is a potent aza-peptide Michael acceptor inhibitor of asparaginyl endopeptidase (AE). It demonstrates nanomolar IC50 values against AEs from Trichomonas vaginalis (4.5 nM), Ixodes ricinus (4.5 nM), and Schistosoma mansoni (31 nM). This compound is a valuable research tool for studying cysteine protease function in parasitology and for inhibitor development in vitro.

Research Area

Infectious Disease & Virology, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 685543-66-2
• MW: 491.49
• Purity: 98.80% (May vary between batches)
• Formula: C₂₂H₂₉N₅O₈
• SMILES: CCOC(=O)\C=C\C(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
• Target: Parasite,Gamma-secretase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.14 mM);DMSO:112.5 mg/mL (228.9 mM)

Bioactivity

• Target IC50:
  AE (ixodes ricinus):4.5 nM |AE1 (Trichomonas Vaginalis):4.5 nM |AE (Schistosoma mansoni):31 nM
• In Vivo:
  RR-11a analog shows a t1/2 of 3-10 min.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Parasite, aza-peptide Michael acceptor, 7a, AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus, AE in Schistosoma mansoni, RR-11a analog

Compound Identifiers

PubChem CID

11294791