RQ-00203078

SKU: orb1306763

Description

RQ-00203078 is a potent and selective oral antagonist of the TRPM8 ion channel. It is a valuable research tool for investigating TRPM8's role in vivo and in vitro, particularly in areas such as cold sensation, migraine, and urological disorders.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1254205-52-1
• MW: 554.85
• Purity: 99.17%
• Formula: C₂₁H₁₃ClF₆N₂O₅S
• SMILES: OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F
• Target: TRP/TRPV Channel
• Solubility: DMSO:50 mg/mL (90.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.6 mM)

Bioactivity

• Target IC50:
  TRPM8 (human channels):8.3 nM|TRPV4:10 μM|TRPM8 (rat channels):5.3 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RQ 00203078, RQ00203078, RQ-00203078, Transient receptor potential channels, TRPV Channel, TRPVChannel, TRPChannel, TRPM8, TRP Channel, Ca2+, menthol, Inhibitor, invasion, inhibit, oral, migration

Compound Identifiers

PubChem CID

49783953