RPI-1

SKU: orb1305802

Description

RPI-1 is a potent and selective ATP-competitive inhibitor of the Ret tyrosine kinase. It is utilized in biochemical and cellular assays to investigate Ret-driven signaling pathways and has been employed in preclinical research models to study cancers like medullary thyroid carcinoma.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 269730-03-2
• MW: 297.31
• Purity: 99.59% (May vary between batches)
• Formula: C₁₇H₁₅NO₄
• SMILES: COc1cc2NC(=O)\C(=C/c3ccc(O)cc3)c2cc1OC
• Target: c-RET,Phospholipase,c-Met/HGFR
• Solubility: DMSO:5.5 mg/mL (18.5 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HGFR, medullary, inhibit, kinase, oral, PLCγ, Met, carcinoma, cells, cMet/HGFR, c-Met, cMet, cRET, CTND1, phosphorylation, thyroid, proliferation, RET, RPI 1, RPI1, RPI-1, tyrosine

Compound Identifiers

PubChem CID

1749978