RP 70676

SKU: orb1309149

Description

RP 70676 is a potent small molecule inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), exhibiting IC50 values of 25 nM and 44 nM against rat and rabbit enzymes, respectively. This tool compound is used in biochemical and cellular assays to investigate ACAT's role in cholesterol esterification and lipid metabolism, with applications in atherosclerosis and lipid storage disease research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 136609-26-2
• MW: 416.58
• Purity: 98.89% (May vary between batches)
• Formula: C₂₅H₂₈N₄S
• SMILES: Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1
• Target: Acyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.6 mM);DMSO:125 mg/mL (300.06 mM)

Bioactivity

• Target IC50:
  ACAT (rabbit):44 nM |ACAT (rat):25 nM
• In Vivo:
  In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.
• In Vitro:
  RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RP 70676, RP70676, RP-70676, Rabbit ACAT, Rat ACAT, inhibit, mono- acylglycerol acyltransferase, Inhibitor, ACAT, Acyltransferase, acyl-CoA:cholesterol acyltransferase, Diacylglycerol acyltransferase, Diglyceride acyltransferase

Compound Identifiers

PubChem CID

9844830