Rotundine

SKU: orb1305125

Description

L-(R,S)-Tetrahydropalmatine (Rotundine) is a natural alkaloid isolated from Corydalis yanhusuo. It is widely used in pharmacological research for studying its analgesic and sedative effects, with applications in both in vitro receptor binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 10097-84-4
• MW: 355.43
• Purity: 99.97% (May vary between batches)
• Formula: C₂₁H₂₅NO₄
• SMILES: COC1=C(OC)C=C2C3CC4=C(CN3CCC2=C1)C(OC)=C(OC)C=C4
• Target: 5-HT Receptor|||Dopamine Receptor
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (154.74 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Rotundine displays a higher affinity to dopamine D1 than D2 receptor with Ki of 124 nM and 388 nM, respectively, while the IC50 values are 166 nM (D1) and 1.47 μM (D2), respectively. Rotundine exhibits a weak inhibitory activity against dopamine D3 with IC50 of 3.25 μM. Rotundine also potently inhibits 5-HT1A with IC50 of 374 nM and Ki of 340 nM. In addition to the antagonism of postsynaptic dopamine receptors, inhibition of presynaptic autoreceptors by Rotundine leads to increased dopamine release, which is probably attributed to lower affinity of Rotundine for D2 receptors. Along with dopamine receptors, Rotundine can interact with a number of other receptor types, including α-1 adrenergic receptors, at which it functions as an antagonist, and γ-aminobutyric acid receptors, at which it facilitates γ-aminobutyric acid binding through positive allosteric effects.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rotundine, TETRAHYDROPALMATINE Hydrochloride, TETRAHYDROPALMATINE HYDROCHLORIDE, 5HTReceptor, 5HT Receptor, 5-HT1A, Dopamine Receptor, DopamineReceptor, D1, D2, D3, L-Tetrahydropalmatine

Compound Identifiers

PubChem CID

5417