Rotigotine (b)

SKU: orb1217469

Description

Rotigotine is an antiparkinson agent and dopamine receptor agonist.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 92206-54-7
• MW: 315.47
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₅NOS
• SMILES: CCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2
• Target: Dopamine Receptor

Bioactivity

• In Vitro:
  Rotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-

Quick Database Links

Gene Symbol

Dopamine Receptor