Rosiglitazone maleate

SKU: orb1307989

Description

Rosiglitazone maleate

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 155141-29-0
• MW: 473.50
• Purity: 99.76%
• Formula: C₂₂H₂₃N₃O₇S
• SMILES: C(=C\C(O)=O)\C(O)=O.C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2
• Target: TRP/TRPV Channel,Ferroptosis,PPAR,Autophagy
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.97 mM);DMSO:87 mg/mL (183.74 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PPARγ1:30 nM (EC50)|PPARγ:42 nM|PPARγ2:100 nM (EC50)
• In Vivo:
  In numerous cell lines, Rosiglitazone has been found to inhibit cholesterol synthesis. It activates the AMP-activated protein kinase (AMPK) complex, which includes the α1 and α2 subunits within the AMPKα subunit, leading to an increase in phosphorylation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ferroptosis, BRL 49653, BRL 49653C, BRL49653, BRL-49653, Autophagy, PPARγ, PPAR, Rosiglitazone, TRPVChannel, TRPV Channel, TRP Channel, TRPChannel

Compound Identifiers

PubChem CID

5281055