LDR102

SKU: orb3134620

Description

LDR102 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki value of 0.10 μM. LDR102 inhibits the proliferation of the cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. LDR102 has demonstrated antitumor activity in mouse models and exhibits favorable pharmacokinetic properties in rats.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3053223-31-4
• MW: 541.6
• Purity: 97.42% (May vary between batches)
• Formula: C₃₃H₂₇N₅O₃
• SMILES: O=C(NC=1C=CC=2C(=CN(C2C1)C)C=3C=CC(OCOC)=CC3)C4=CC=C(C(C#CC5=CC=NC=6NN=CC56)=C4)C
• Target: ROR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROR