Ropinirole hydrochloride

SKU: orb1223664

Description

Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.(In Vitro):Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.(In Vivo):Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.

Key Properties

• CAS Number: 91374-20-8
• MW: 296.84
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₄N₂O·HCl
• SMILES: O=C(NC/1=O)SC1=C\C2=CC=C(OCO3)C3=C2
• Target: Dopamine Receptor
• Solubility: Water: 60 mg/mL (202.12 mM); DMSO: 10 mg/mL (33.68 mM)

Bioactivity

• In Vivo:
  Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic-and antidepressive-like effects without affecting motor activity or spatial memory. Animal model: Male Sprague–Dawley rats weighing 220-350 g. Dosage: 0.1, 1 or 10 mg/kg. Administration: i.p. Result: Decreased ICSS thresholds and induced anxiolytic-and antidepressive-like effects without affecting motor activity or spatial memory.
• In Vitro:
  Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKF 101468A

Quick Database Links

Gene Symbol

Dopamine Receptor