Rolapitant

SKU: orb1303855

Description

Rolapitant hydrochloride is a selective neurokinin-1 (NK1) receptor antagonist used in research to study antiemetic mechanisms. It is applied in preclinical models of chemotherapy-induced nausea and vomiting (CINV), with studies demonstrating its efficacy in both in vitro binding assays and in vivo animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 552292-08-7
• MW: 500.48
• Purity: 99.86% (May vary between batches)
• Formula: C₂₅H₂₆F₆N₂O₂
• SMILES: [H][C@](C)(OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
• Target: Neurokinin receptor
• Solubility: DMSO:55 mg/mL (109.89 mM)

Bioactivity

• Target IC50:
  NK1:0.66 nM. (Ki)
• In Vivo:
  Rolapitant reverses NK1 agonist-induced foot tapping in gerbils following both intravenous and oral administration up to 24 hours at a minimal effective dose (MED) of 0.1 mg/kg. Rolapitant is active at 0.1 and 1 mg/kg in both acute and delayed emesis models in ferrets, respectively which is the same as clinical data for other NK1 antagonists. The clinical efficacy of anti-emetics is highly correlated with efficacy in the ferret emesis model, suggesting rolapitant is a viable clinical candidate for this indication.
• In Vitro:
  Rolapitant has a high affinity for the human NK1 receptor with a Ki of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of more than 1000-fold. Rolapitant has a preferential affinity for human, guinea pig, gerbil, and monkey NK1 receptors over rat, mouse, and rabbit.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

long-acting, inhibit, orally active, NK receptor, NK1, Neurokinin receptor, Neurokinin Receptor, Neurokininreceptor, Mongolian Gerbils, Inhibitor, emesis, ferret, foot tapping, anti-emetic, retches, Rolapitant, SCH 619734, SCH619734, SCH-619734, Tachykinin receptor, vomits

Compound Identifiers

PubChem CID

10311306