Rofecoxib

• Catalog Number: orb1309482
• Category: Small Molecules
• Description: Rofecoxib
• CAS Number: 162011-90-7
• Purity: 99.94%
• MW: 314.36
• SMILES: O=C1C(=C(CO1)C2=CC=C(S(C)(=O)=O)C=C2)C3=CC=CC=C3
• Formula: C₁₇H₁₄O₄S
• Biological Activity: Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.