Rocuronium bromide

SKU: orb1310887

Description

Rocuronium bromide is a non-depolarizing aminosteroid neuromuscular blocking agent. It is primarily used in clinical and research settings to induce muscle relaxation for procedures like endotracheal intubation during surgery or mechanical ventilation. Its applications extend to pharmacological studies investigating neuromuscular transmission in both in vivo and in vitro experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 119302-91-9
• MW: 609.68
• Purity: >99.99% (May vary between batches)
• Formula: C₃₂H₅₃BrN₂O₄
• SMILES: [Br-].[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)[C@H](C[C@]12C)N1CCOCC1)[N+]1(CC=C)CCCC1
• Target: AChR
• Solubility: H2O:112 mg/mL (183.7 mM);DMSO:113 mg/mL (185.34 mM);Ethanol:113 mg/mL (185.34 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (5.41 mM)

Bioactivity

• In Vitro:
  Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner . It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects . The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, ORG 9426, ORG 9426 (Bromide), ORG9426, ORG-9426, mAChR, Rocuronium, Rocuronium Bromide, Rocuronium bromide

Compound Identifiers

PubChem CID

441351