ROCK2-IN-14

SKU: orb3210075

Description

ROCK2-IN-14 is an orally bioavailable and selective ROCK2 inhibitor with an IC50 of 4.8 nM, and it is 212 times more selective for ROCK2 over ROCK1 (IC50=1.01 μM). By inhibiting the ROCK2/S100A9 signaling pathway, ROCK2-IN-14 reduces S100A9 expression, inhibits NM2 phosphorylation, and corrects cytoskeletal abnormalities. Consequently, it lowers levels of inflammatory cytokines, alleviates skin inflammation, and exhibits anti-inflammatory effects. In atopic dermatitis (AD) mouse models, ROCK2-IN-14 significantly reduces ear thickening and decreases IgE, TNF-α, IL-6, and TSLP levels. The compound demonstrates good safety, with a maximum tolerable oral dose exceeding 500 mg/kg, making it a potential candidate for atopic dermatitis research.

Key Properties

• CAS Number: 3115784-59-0
• MW: 434.55
• Formula: C₂₄H₂₆N₄O₂S
• SMILES: O=C(NCC=1C=CC=C(OCCCN(C)C)C1)C=2SC3=CC(=CC=C3C2)C=4C=NNC4
• Target: ROCK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROCK