ROCK inhibitor-2

SKU: orb1309156

Description

ROCK inhibitor-2 is a potent and selective small molecule targeting both ROCK1 and ROCK2 kinases, with respective IC50 values of 17 nM and 2 nM. It is widely used in cardiovascular, neurological, and cancer research, facilitating studies on cytoskeletal dynamics in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1127308-52-4
• MW: 332.4
• Purity: 99.87% (May vary between batches)
• Formula: C₂₁H₂₀N₂O₂
• SMILES: COc1cccc(c1)[C@@H](C)NC(=O)c1ccc(cc1)-c1ccncc1
• Target: ROCK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.04 mM);DMSO:250 mg/mL (752.11 mM)

Bioactivity

• Target IC50:
  ROCK1:17 nM|ROCK2:2 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Rho-kinase, Rho-associated protein kinase, Rho-associated kinase, ROCK2, ROK, ROCK1, ROCK inhibitor 2, ROCK inhibitor2, ROCK inhibitor-2, ROCK

Compound Identifiers

PubChem CID

51003130