Roblitinib

SKU: orb1303035

Description

Roblitinib (FGF-401) is a selective FGFR4 inhibitor with antineoplastic potential. It suppresses tumor cell proliferation in FGFR4-overexpressing models and is used in research targeting hepatocellular carcinoma and other solid tumors, both in vitro and in vivo.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1708971-55-4
• MW: 506.56
• Purity: 99.00% (May vary between batches)
• Formula: C₂₅H₃₀N₈O₄
• SMILES: COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
• Target: FGFR
• Solubility: Ethanol:0.83 mg/mL (1.64 mM);DMSO:2 mg/mL (3.95 mM)

Bioactivity

• Target IC50:
  FGFR2:>10 μM|FGFR1:>10 μM|FGFR3:>10 μM|FGFR4:1.1 nM
• In Vivo:
  FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II Clinicalal studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JHH, JHH7, inhibit, Inhibitor, HUH7, FGF 401, FGFR, FGF401, FGF-401, FGFR4, Fibroblast growth factor receptor, Hep3B, HEPG2, C552A, Roblitinib

Compound Identifiers

PubChem CID

118036971