Robinin

SKU: orb1221592

Description

Robinin is a flavone glycoside based on kaempferol.

Key Properties

• CAS Number: 301-19-9
• MW: 740.66
• Purity: >98% (HPLC)
• Formula: C₃₃H₄₀O₁₉
• SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C6=CC=C(C=C6)O)O)O)O)O)O)O
• Target: Others
• Solubility: In Vitro: DMSO : 250 mg/mL (337.54 mM)

Bioactivity

• In Vivo:
  Animal model: Adjuvant arthritis mice model. Dosage: 50 mg/kg Robinin and 0.3 mg/kg MTX twice a week. Administration: Oral gavage (p.o.). Result: Had anti-inflammatory and anti-arthritic action. Animal model: Sprague Dawley rats model. Dosage: 50 mg/kg Robinin for 10 days. Administration: Oral gavage (p.o.). Result: Reduced the cardiotoxic effects of Doxorubicin-induced.
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• In Vitro:
  Western blot analysis. Cell line: hPBMCs. Concentration: 6 μg/mL. Incubation time: 24 h. Result: Inhibited the upregulated expression of MCP 1, TNF-α, IL-6 and ICAM-1 with anti-inflammatory properties. Cell Viability Assay Cell line: hPBMCs. Concentration: 1 μg/mL, 2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL, 10 μg/mL. Incubation time: 24 h. Result: Concentration from 1 μg/ml-10 μg/ml on hPBMCs had no obvious cytotoxicity. RT-PCR Cell line: hPBMCs. Concentration: 1 μg/mL, 2 μg/mL, 4 μg/mL, 6 μg/mL, 8 μg/mL, 10 μg/mL. Incubation time: 24 h. Result: Inhibited the upregulated expression of TLR2 and TLR4.Cell Proliferation Assay Cell line: Mia-PACA2 and PANC-1. Concentration: 1 μM. Incubation time: 24 h. Result: Inhibited cell proliferation. Cell Migration Assay Cell line: Mia-PACA2 and PANC-1. Concentration: 1 μM. Incubation time: 24 h. Result: Decreased the cell migration area
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EINECS 206-113-3 | NSC 9222 | Robinin

Quick Database Links

Gene Symbol

Others