RO8994

SKU: orb1304126

Description

RO8994 is a potent and selective spiroindolinone-based MDM2 inhibitor, exhibiting IC50 values of 20 nM in MTT proliferation assays and 5 nM in HTRF binding assays. This compound is a valuable research tool for studying p53-MDM2 interactions in cancer biology, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1309684-94-3
• MW: 613.51
• Purity: 99.44% (May vary between batches)
• Formula: C₃₁H₃₁Cl₂FN₄O₄
• SMILES: COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O
• Target: Apoptosis,MDM-2/p53,p53,E1/E2/E3 Enzyme,Mdm2
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM);DMSO:50 mg/mL (81.5 mM)

Bioactivity

• Target IC50:
  MDM2:20 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Mdm2, MDM-2/p53, inhibit, P53, E3 ligating enzyme, E3Enzyme, E2 Enzyme, E2 conjugating enzyme, E2Enzyme, E3 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E1 activating enzyme, E1 Enzyme, RO 8994, RO8994, RO-8994, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase

Compound Identifiers

PubChem CID

53238217