RO8191

SKU: orb1306082

Description

RO8191 (CDM-3008) is a small molecule agonist of the interferon receptor. It activates IFN signaling pathways and is utilized in immunological and antiviral research, demonstrating activity in both cellular assays and animal models of viral infection.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 691868-88-9
• MW: 373.21
• Purity: 98.85% (May vary between batches)
• Formula: C₁₄H₅F₆N₅O
• SMILES: FC(F)(F)C1=CC(=C2C=CC3=NC(=CN3C2=N1)C1=NN=CO1)C(F)(F)F
• Target: IFNAR,JAK,HBV,HCV Protease,STAT
• Solubility: DMSO:3 mg/mL (8.04 mM)

Bioactivity

• In Vivo:
  RO8191 significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.
• In Vitro:
  RO8191 strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDM 3008, CDM3008, CDM-3008, cccDNA, Inhibitor, JAK, JAK1, Janus kinase, inhibit, ISGs, orally, EMCV, IFNAR1, IFNAR2, IFNAR, interferon, HCV, HCVProtease, HCV Protease, Hepatitis C virus, Hepatitis B virus, Interferon-alpha/beta receptor, Interferon-α/β receptor, HBV, imidazonaphthyridine, STAT, RO8191, RO-8191, RO4948191, RO-4948191, RO 4948191, RO 8191, replicon, Tyk2

Compound Identifiers

PubChem CID

2768133