RO5234444

SKU: orb3173749

Description

RO5234444 is an orally active CCR2 antagonist, exhibiting an IC50 of 22 nM for human CCR2 and 161 nM for mouse CCR2. It mitigates glomerulosclerosis in a unilateral nephrectomy type 2 diabetes db/db mouse model, reduces proteinuria, and significantly improves glomerular filtration rate. RO5234444 is applicable for research in type 2 diabetic nephropathy.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1365266-79-0
• MW: 463.98
• Formula: C₂₄H₃₁ClFN₃O₃
• SMILES: O[C@H]1C2(CC2)CCN(CCCN3C(=O)[C@H](C)N(C(C=CC4=CC(Cl)=C(F)C=C4)=O)CC3)C1
• Target: CCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CCR