RO5068760

SKU: orb1741214

Description

RO5068760 is a potent, non-ATP-competitive, and highly selective MEK1/2 inhibitor of the substituted hydantoin class. It demonstrates strong in vitro activity (IC50 = 0.025 μM) and shows superior efficacy in vivo against tumors driven by aberrant MAPK signaling, particularly those harboring the B-Raf V600E mutation.

Key Properties

• CAS Number: 947182-25-4
• MW: 647.43
• Formula: C₂₈H₂₇FIN₃O₆
• SMILES: [C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=C(F)C=C(I)C=C2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OC[C@@H](CO)O)C=C4
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

17757766