Ro5-3335

SKU: orb1302652

Description

Ro5-3335 is a small molecule inhibitor of the RUNX1/CBFβ transcription factor complex. It selectively targets leukemia cells harboring CBF fusions, demonstrates efficacy in reducing leukemia burden in mouse models, and also acts as a Tat antagonist to inhibit HIV-1 replication in vitro.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 30195-30-3
• MW: 259.69
• Purity: 99.95% (May vary between batches)
• Formula: C₁₃H₁₀ClN₃O
• SMILES: Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1
• Target: DNA/RNA Synthesis,Others
• Solubility: DMSO:60 mg/mL (231.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.7 mM)

Bioactivity

• Target IC50:
  CBF:1.1 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

core, CBFβ-Runx1, CBFβ-Runx1 inhibitor II, CBFbeta-Runx1 inhibitor II, CBFb-Runx1 inhibitor II, CBFβ, DNASynthesis, DNA Synthesis, binding, CBF, Inhibitor, interaction, leukemia, factor, inhibit, RNA Synthesis, RNASynthesis, Ro 5-3335, RUNX1, RUNX1-CBFB, Ro5 3335, Ro53335, Ro-5-3335, Ro5-3335

Compound Identifiers

PubChem CID

64983