RO4927350

SKU: orb1741021

Description

RO4927350 is a potent, selective non-ATP-competitive MEK1/2 inhibitor that suppresses MAPK signaling and demonstrates antitumor efficacy in diverse preclinical models. It uniquely inhibits basal and feedback-induced MEK phosphorylation, making it a valuable research tool for studying cancers driven by aberrant MAPK pathway activation in both cellular and animal studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 876755-27-0
• MW: 536.6
• Formula: C₂₇H₂₈N₄O₆S
• SMILES: [C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=NC(C(CC)=O)=CS2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OCCO)C=C4
• Target: MEK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11526671