RO2443

SKU: orb1738754

Description

RO2443 is a small molecule that disrupts the p53-MDM2/MDMX interactions by inducing dimerization of these negative regulators, thereby reactivating the p53 tumor suppressor pathway. It serves as a valuable chemical probe for studying p53 biology in cancer research and has demonstrated activity in both cellular assays and in vivo tumor models.

Key Properties

• CAS Number: 1416663-79-0
• MW: 401.79
• Formula: C₂₀H₁₄ClF₂N₃O₂
• SMILES: C(C=1C=2C(=C(C)C(Cl)=CC2)NC1)=C3C(=O)N(CC4=CC(F)=C(F)C=C4)C(=O)N3
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

136683437