RO-5963

SKU: orb1706705

Description

RO-5963 is a potent small molecule dual inhibitor of the p53-MDM2 and p53-MDMX interactions, with IC50 values of approximately 17 nM and 24 nM, respectively. It is a valuable research tool for reactivating p53 function in cancer cell studies and has demonstrated efficacy in preclinical in vivo tumor models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1416663-77-8
• MW: 518.9
• Purity: 98.00% (May vary between batches)
• Formula: C₂₄H₂₁ClF₂N₄O₅
• SMILES: C(C(NC(CO)CO)=O)(N1C(=O)C(=CC=2C=3C(NC2)=C(C)C(Cl)=CC3)NC1=O)C4=CC(F)=C(F)C=C4
• Target: E1/E2/E3 Enzyme,MDM-2/p53,Mdm2,p53
• Solubility: DMSO:50 mg/mL (96.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.36 mM)

Bioactivity

• Target IC50:
  p53-MDM2:~17 nM|p53-MDMX:~24 nM
• In Vitro:
  RO-5963 (10 μM, 24 hours) potently activates p53 and elevates p21 and MDM2 levels. RO-5963 (10-20 μM; 48 hours) displays much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RO5963, RO-5963, RO 5963, MDMX, Mdm2, p53-MDM2, p53-MDMX, p53

Compound Identifiers

PubChem CID

136683438