Ro 48-8071 fumarate

SKU: orb1225821

Description

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical

Key Properties

• CAS Number: 189197-69-1
• MW: 564.4406
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₁BrFNO₆
• SMILES: O=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
• Target: Oxidosqualenecyclase
• Solubility: DMSO: ≥ 55 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro-488071 fumarate

Quick Database Links

Gene Symbol

Oxidosqualenecyclase