RO 20-1724

SKU: orb1306924

Description

Ro 20-1724 is a potent and selective phosphodiesterase inhibitor with an IC50 of 2.0 µM. It is widely used in biochemical research to elevate intracellular cAMP levels, facilitating studies in cell signaling, neurobiology, and smooth muscle physiology in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 29925-17-5
• MW: 278.4
• Purity: >98%
• Formula: C₁₅H₂₂N₂O₃
• SMILES: CCCCOC1=C(OC)C=CC(CC2CNC(=O)N2)=C1
• Target: PDE (Phosphodiesterase)
• Solubility: Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 40 mg/ml).

Bioactivity

• Target IC50:
  PDE4:2.0 μM|PDE4:3.1 μM(Ki)
• In Vivo:
  RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

phosphodiesterase, Phosphodiesterase (PDE), Ro 20 1724, Ro 201724, Ro 20-1724, Ro 20-174, Ro-20-1724, Ro20-1724, PDE4, neuroprotective, inhibit, Inhibitor, cognitive, cAMP, antioxidant, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Compound Identifiers

PubChem CID

5087