Ro 10-5824 dihydrochloride

SKU: orb1309150

Description

Ro 10-5824 dihydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 189744-94-3
• MW: 353.29
• Purity: 99.95% (May vary between batches)
• Formula: C₁₇H₂₂Cl₂N₄
• SMILES: Cl.Cl.Cc1ncc(CN2CCC(=CC2)c2ccccc2)c(N)n1
• Target: Dopamine Receptor
• Solubility: H2O:60 mg/mL (169.83 mM);DMSO:8.33 mg/mL (23.58 mM)

Bioactivity

• Target IC50:
  D4 receptor:5.2 nM (ki)
• In Vivo:
  The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.
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• In Vitro:
  RO-10-5824 exhibits high affinity binding (Ki=5.2±0.9 nM (n=3)), 250-fold selectivity over human D3R, and >1000-fold selectivity for D4 versus human D2, D1, and D5 receptors. It stimulates 35S-GTPγS binding (EC50: 205±67 nM) (n=7) with a maximal induction of 36±4% above basal level .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D4, DopamineReceptor, Dopamine Receptor, dopamine D4 receptor, Inhibitor, inhibit, Ro 10 5824 dihydrochloride, Ro 10-5824, Ro 105824 dihydrochloride, Ro 10-5824 Dihydrochloride

Compound Identifiers

PubChem CID

16759174