Ro 08-2750

SKU: orb1307786

Description

Ro 08-2750 is a reversible, non-peptide inhibitor of nerve growth factor (NGF) with an IC50 of ~1 µM, selectively blocking its binding to p75NTR over TrkA. It also inhibits MSI RNA-binding activity (IC50=2.7 µM). This small molecule is used in vitro to study neurotrophin signaling and oncogenic RNA-binding proteins in cancer and neuroscience research.

Research Area

Cell Biology

Key Properties

• CAS Number: 37854-59-4
• MW: 270.24
• Purity: 98.80% (May vary between batches)
• Formula: C₁₃H₁₀N₄O₃
• SMILES: Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O
• Target: Apoptosis,Others
• Solubility: DMSO:3.5 mg/mL (12.95 mM)

Bioactivity

• Target IC50:
  NGF:~1 μM
• In Vivo:
  In a myeloid leukemia model in vivo, Ro 08-2750 (13.75 mg/kg; i.p.) suppresses leukemogenesis .
• In Vitro:
  Ro 08-2750 inhibits the survival of human AML lines and patient cells. Ro 08-2750 suppresses MSI2 RNA-binding and alters the MSI2 gene signature. Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore. Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells. Ro 08-2750 (10 nM) fully rescues cells from undergoing NGF-induced SK-N-MC 103 cell death .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AML, leukemia, Inhibitor, growth, factor, MUSASHI, MSI, inhibit, p75NTR, NGF, Nerve, RNA-binding, Ro 08 2750, Ro 082750, Ro 08-2750, TRKA

Compound Identifiers

PubChem CID

17756791